laisa andriol – synthetic glucocorticosteroid topical anti-inflammatory, anti-allergic and immunosuppressive effect. Increases production lipomodulina, an inhibitor of phospholipase A, inhibits the release of arachidonic acid. It prevents the accumulation of neutrophils boundary, reduces the inflammatory exudation and production of lymphokines inhibits the migration of macrophages, reduces the intensity of infiltration and granulation processes, the formation of chemotactic substances. Reduces nasal mucosa swelling, mucus production. It improves mucociliary transport. It has fungicidal action. Well tolerated in long-term treatment is not mineralocorticoid activity, almost no resorptive action.
Absorption is low. Gets into the digestive tract of the full (90%) breaks down (inactive metabolites are formed), the “first pass” through the liver. Bioavailability – 10% of the amount released to the stomach and 28% – for pulmonary fraction. TA max – 15-45 minutes after intranasal administration. Relationship to plasma proteins – 88%. It has a high systemic clearance – 84 l / h. T1 / 2 -. 2.8 h C max – 0,01 mmol / L. Is displayed through the intestine as metabolites – 10% kidney – 70%.
seasonal and perennial allergic rhinitis.
Hypersensitivity to the drug.
Fungal, bacterial and viral respiratory infections.
Dosing and Administration
Benarin applied intranasally with 18 years. Single dose Benarina depending on the severity of the disease is 60-120 mcg of laisa andriol, 2-3 drops in each buy andriol testocaps nostril. The daily dose is selected individually, taking into account the severity of rhinitis, usually enough two single doses per day. The duration of 10-14 days depending on the severity of rhinitis.
The maximum single dose of 200 micrograms (100 mcg in each nostril), the maximum daily dose of 400 mg for a maximum of 3 months.
Burning, irritation of the nose, sneezing, candidiasis.
With prolonged use of high doses, as well as while receiving andriol for sale other systemic corticosteroids may appear in Cushing’s symptoms. In this case, the reception Benarina should be discontinued gradually reducing the dose.
is recommended to avoid contact with eyes.
Interaction with other drugs
phenobarbital, phenytoin, rifampin reduce the effectiveness (induction of enzymes of microsomal oxidation). Methandrostenolone, estrogens increase the effect of laisa andriol.
in 5.0 or 10.0 ml glass vials, bottles of dark glass or plastic dropper bottles. Each bottle with pipette dropper or cover with instructions for use placed in a pack. Each vial-dropper is placed in the pack.
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